Adventitious Agents and Smallpox Vaccine in Strategic National Stockpile
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Adventitious Agents and Smallpox Vaccine in Strategic National Stockpile
In keeping with current standards, we urge that old smallpox vaccines that were made in animal skin and are still a key part of our strategic national stockpile be tested for adventitious infectious agents. The advisory especially applies to viruses that have the potential for zoonotic transmission to human vaccine recipients.
متن کاملAdventitious Viruses and Smallpox Vaccine
To the Editor: Recently, Murphy and Osburn (1) strongly argued for testing old smallpox vaccine stocks made in animal skin for adventitious infectious agents such as viruses, mycoplasmas, and eventually, prions. Their argument appears clearly justified after unexpected cases of myopericarditis occurred during recent campaigns of smallpox vaccinations in the United States (2). To the long list o...
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Smallpox was eradicated more than 30 years ago, but heightened concerns over bioterrorism have brought smallpox and smallpox vaccination back to the forefront. The previously licensed smallpox vaccine in the United States, Dryvax (Wyeth Laboratories, Inc.), was highly effective, but the supply was insufficient to vaccinate the entire current US population. Additionally, Dryvax had a questionabl...
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متن کاملAdventitious agents and vaccines.
Emerging Infectious Diseases Vol. 7, No. 3 Supplement, June 2001 562 A discussion of adventitious agents and vaccines is pertinent in the context of emerging infectious diseases. Many novel vaccines are produced in animal cell substrates, and emerging infectious diseases may theoretically be transmitted from animals to humans through these vaccines. The challenge of identifying potential advent...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2007
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1107.050277